Synthesis of sulfazecin-type 2-azetidinones with a carbon substituent at the 4-position.

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Synthesis of sulfazecin-type 2-azetidinones with a carbon substituent at the 4-position.

Sir: As reported in our previous paper,1) chemical modification of sulfazecin2) at the 3-position significantly enhanced its antibacterial activity; however, further improvement was desired especially in regard to the stability to some p-lactamases. We focused our attention on modifying the unexplored 4-position, and cis-1-(2,4dimethoxybenzyl)4methoxycarbonyl3 -phthalimido-2-azetidinone (1a) wa...

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Synthesis and Antifungal Activity of Some Azetidinones

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ژورنال

عنوان ژورنال: The Journal of Antibiotics

سال: 1983

ISSN: 0021-8820,1881-1469

DOI: 10.7164/antibiotics.36.1421